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脂肪干细胞衰老及其在神经再生的影响

2014-08-04 02:34:18| 分类：生命医学 | 标签： |举报 |字号大中小订阅

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意大利米兰大学Magnaghi教授所在课题组提出了多种影响干细胞衰老的关键性因素，它们可以影响ASC的形态和功能，并协调其在周围神经再生细胞治疗中的临床应用。

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　　与细胞衰老，细胞死亡，细胞凋亡以及环境刺激相关的细胞内关键信号途径示意图。(图片来源：《中国神经再生研究(英文版)》杂志)

　　成人脂肪干细胞(ASC)具有自我更新和多向分化的潜力，许多研究已显示出其在再生医学治疗中的作用，尤其是在周围神经再生的应用中，属于理想的候选治疗方式，但ASC的潜在神经修复能力易受细胞衰老或捐赠者年龄的限制。

　　意大利米兰大学Magnaghi教授所在课题组提出了多种影响干细胞衰老的关键性因素，它们可以影响ASC的形态和功能，并协调其在周围神经再生细胞治疗中的临床应用。相关研究观点文章发表在2014年1月第1期《中国神经再生研究(英文版)》杂志上。(来源：生物帮)

　　原文摘要：

Senescence in adipose-derived stem cells and its implications in nerve regeneration

Cristina Mantovani, Giorgio Terenghi, Valerio Magnaghi

　　Adult mesenchymal stem cells, specifically adipose-derived stem cells have self-renewal and multiple differentiation potentials and have shown to be the ideal candidate for therapeutic applications in regenerative medicine, particularly in peripheral nerve regeneration. Adipose-derived stem cells are easily harvested, although they may show the effects of aging, hence their potential in nerve repair may be limited by cellular senescence or donor age. Cellular senescence is a complex process whereby stem cells grow old as consequence of intrinsic events (e.g., DNA damage) or environmental cues (e.g., stressful stimuli or diseases), which determine a permanent growth arrest. Several mechanisms are implicated in stem cell senescence, although no one is exclusive of the others. In this review we report some of the most important factors modulating the senescence process, which can influence adipose-derived stem cell morphology and function, and compromise their clinical application for peripheral nerve regenerative cell therapy.

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